The author's Stocks and Shares ISA is experiencing a pivotal week with several key holdings reporting first-quarter earnings. The article delves into the performance of these companies, highlighting a divergence between London-listed stocks and their U.S. counterparts. HSBC and IHG have surged, while Axon Enterprise, Duolingo, MercadoLibre, and Shopify have underperformed, with some stocks down significantly from their 52-week highs. The author attributes this to the perceived lack of AI disruption risk for traditional businesses like HSBC and IHG, contrasting with the software-oriented companies that have been negatively impacted by investor nervousness about AI. The author remains optimistic about the long-term prospects of these holdings, particularly Shopify, which is expected to report significant growth in platform sales, and Axon Enterprise, which plays a crucial role in public safety and security. Duolingo's focus on user growth over profits is seen as a strategic move, despite the risk of accelerated user growth not materializing. The author expresses confidence in Duolingo's profitability and category leadership, considering it a compelling investment opportunity at a discounted valuation. The article concludes by emphasizing the importance of a long-term perspective in investing, encouraging readers to focus on the fundamental strengths of companies rather than short-term market fluctuations.